The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study
Identifieur interne : 000901 ( Main/Corpus ); précédent : 000900; suivant : 000902The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study
Auteurs : Thomas Foltynie ; Carol E. G. Brayne ; Trevor W. Robbins ; Roger A. BarkerSource :
- Brain [ 0006-8950 ] ; 2004-03.
English descriptors
- KwdEn :
- CI = confidence interval; DLB = dementia with Lewy bodies; MMSE = Mini‐Mental State Examination; NART = National Adult Reading test; PDBB = Parkinson’s disease Brain Bank; PRM = pattern recognition memory; SRM = spatial recognition memory; PDD = patients with Parkinson’s disease and dementia; TOL = Tower of London task; UPDRS = Unified Parkinson’s Disease Rating Scale, incidence; Parkinson’s disease; parkinsonism; cognitive.
Abstract
We have used multiple sources to identify a population‐representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2‐year period. All patients have been invited to participate in a detailed clinical assessment either at home or in an outpatient clinic. These assessments have been used to refine clinical diagnoses of parkinsonism using established criteria, and describe some of the phenotypic variability of Parkinson’s disease at the time of diagnosis. The crude incidence of Parkinson’s disease was 13.6/105yr–1 [confidence interval (CI) 11.8–15.6 and of parkinsonism was 20.9/105yr–1 (CI 18.7–23.3). Age‐standardized to the 1991 European population, the incidence figures become 10.8/105yr–1 (CI 9.4–12.4) for Parkinson’s disease and 16.6/105yr–1 (CI 14.8–18.6) for parkinsonism. Thirty‐six per cent of the Parkinson’s disease patients had evidence of cognitive impairment based on their performance in the Mini‐Mental State Examination, a pattern recognition task, and the Tower of London task. The pattern of cognitive deficits seen among these patients using these and further cognitive tasks suggests that sub‐groups of patients based on cognitive ability might be identifiable even in the early stages of disease, which may reflect regional differences in the underlying neuropathological processes.
Url:
DOI: 10.1093/brain/awh067
Links to Exploration step
ISTEX:2AD78475F86EC4C46E2546C8F5C46FDFC15C68D1Le document en format XML
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The CamPaIGN study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Foltynie</surname><given-names>Thomas</given-names></name><xref rid="AWH067A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Brayne</surname><given-names>Carol E. G.</given-names></name><xref rid="AWH067A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Robbins</surname><given-names>Trevor W.</given-names></name><xref rid="AWH067A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Barker</surname><given-names>Roger A.</given-names></name><xref rid="AWH067A1">1</xref></contrib><aff id="AWH067A1"><label>1</label>Cambridge Centre for Brain Repair,</aff><aff id="AWH067A2"><label>2</label>Department of Public Health and Primary Care, Institute of Public Health and</aff><aff id="AWH067A3"><label>3</label>Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK</aff></contrib-group><author-notes><corresp id="COR1"><label></label>Correspondence to: T. Foltynie, Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK E‐mail: <ext-link xlink:href="tf210@medschl.cam.ac.uk" ext-link-type="email">tf210@medschl.cam.ac.uk</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>03</month><year>2004</year></pub-date><volume>127</volume><issue>3</issue><fpage>550</fpage><lpage>560</lpage><history><date date-type="accepted"><day>23</day><month>10</month><year>2003</year></date><date date-type="received"><day>01</day><month>08</month><year>2003</year></date><date date-type="rev-recd"><day>21</day><month>08</month><year>2003</year></date></history><copyright-statement>The Guarantors of Brain 2004</copyright-statement><copyright-year>2004</copyright-year><abstract xml:lang="en"><p>We have used multiple sources to identify a population‐representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2‐year period. All patients have been invited to participate in a detailed clinical assessment either at home or in an outpatient clinic. These assessments have been used to refine clinical diagnoses of parkinsonism using established criteria, and describe some of the phenotypic variability of Parkinson’s disease at the time of diagnosis. The crude incidence of Parkinson’s disease was 13.6/10<sup>5yr–1</sup> [confidence interval (CI) 11.8–15.6 and of parkinsonism was 20.9/10<sup>5yr–1</sup> (CI 18.7–23.3). Age‐standardized to the 1991 European population, the incidence figures become 10.8/10<sup>5yr–1</sup> (CI 9.4–12.4) for Parkinson’s disease and 16.6/10<sup>5yr–1</sup> (CI 14.8–18.6) for parkinsonism. Thirty‐six per cent of the Parkinson’s disease patients had evidence of cognitive impairment based on their performance in the Mini‐Mental State Examination, a pattern recognition task, and the Tower of London task. The pattern of cognitive deficits seen among these patients using these and further cognitive tasks suggests that sub‐groups of patients based on cognitive ability might be identifiable even in the early stages of disease, which may reflect regional differences in the underlying neuropathological processes.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>incidence; Parkinson’s disease; parkinsonism; cognitive</kwd></kwd-group><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>CI = confidence interval; DLB = dementia with Lewy bodies; MMSE = Mini‐Mental State Examination; NART = National Adult Reading test; PDBB = Parkinson’s disease Brain Bank; PRM = pattern recognition memory; SRM = spatial recognition memory; PDD = patients with Parkinson’s disease and dementia; TOL = Tower of London task; UPDRS = Unified Parkinson’s Disease Rating Scale</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>550</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Article</meta-value></custom-meta></custom-meta-wrap></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The cognitive ability of an incident cohort of Parkinson’s patients in the UK. 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G.</namePart><namePart type="family">Brayne</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Trevor W.</namePart><namePart type="family">Robbins</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger A.</namePart><namePart type="family">Barker</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2004-03</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We have used multiple sources to identify a population‐representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2‐year period. 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|étape= Corpus
|type= RBID
|clé= ISTEX:2AD78475F86EC4C46E2546C8F5C46FDFC15C68D1
|texte= The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study
}}
| This area was generated with Dilib version V0.6.23. |  |